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KMID : 0377619670120060561
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Korean Jungang Medical Journal
1967 Volume.12 No. 6 p.561 ~ p.577
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Study on Genetic Mechanism of the Arthus Reaction
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Abstract
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The experiment was carried out to ascertain whether there exist certain active substance in allergic inflammatory exudate which may evoke inflammatory reaction, and, if any, to study further the nature of inflammation inducing substances. The author prepared allergic inflammatory exudates from various body cavities and saline extract of local allergic tissue, in experimental Arthus reactions of rabbits, and injected the saline extract and exudate into the abdominal skin of normal rabbits with the positive results of inflammatory reaction. Since it was revealed that there exist certain inflammatory agents in both extract and exudate, the author undertook furthur experiment in order to isolate the active substances from them by means of some chemical procedures and paper electrophoresis. The various
substances thus analyzed and fractionated were injected intra-cutaneously into the skin of normal rabbits, and microscopic examination of the lesions produced by the injections was made at different time intervals.
The results obtained are summarized as follows:
1) Extracts obtained from allergic inflammatory exudates were proved to possess inflammation-inducing abilities.
2) Substances chiefly concerned with inflammation-inducing ability were thought to belong to β-globulin fraction.
3) The inflammation-inducing substances were thought to be the products of antigenantibody reaction in living tissue.
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